Study of the Physiology of Pre-eclampsia and Vascular IUGR With Constitution of a Biological Collection

Condition(s) studied

Investigational drug(s) / intervention(s)

collect of placenta, blood and urinary samples at delivery: collect of placenta, blood and urinary samples at delivery

Study summary

Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in France. The consequences in terms of morbidity and perinatal morbidity and the medical and economic costs make it an issue public health. Pre-eclampsia associates maternal hypertension with dysfunction kidney. There is no cure for pre-eclampsia or IUGR vascular during pregnancy. These pathologies invariably evolve towards a maternal and / or fetal aggravation sometimes very fast. Primary prevention and secondary education and screening for these pathologies are still insufficient. A better understanding of the pathophysiology of these placental vascular pathologies is necessary for the development of supported medical, obstetric and pediatric that will improve the state of health maternal and neonatal

Eligibility

Primary outcome measure(s)

• genomic analysis on placenta — day of delivery
  by chromatin immunoprecipitation-sequencing (ChIP-seq)

Trial sites (1)

More Centre Hospitalier Intercommunal Creteil trials in France

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