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Clinical Trials in Egypt / NCT07928856
Starting soon Not applicable

Injectable Platelet-Rich Fibrin As An Adjunct To Minimally Invasive Nonsurgical Treatment In Endodontic-Periodontal Lesions: A Randomized Controlled Trial

NCT07928856 · tracked via the Priya Life Science Egypt tracker
Sponsor
Cairo University
Phase
Not applicable
Started
2026-12-01
Last updated
2026-11-10

Condition(s) studied

Endodontic-Periodontal Lesions

Investigational drug(s) / intervention(s)

Non-invasive application of i PRFNon-surgical endodontic and periodontal treatment

Non-invasive application of i PRF: Non-invasive application of i PRF in endodontic-periodontal lesions

Non-surgical endodontic and periodontal treatment: Non-surgical endodontic treatment followed by non-surgical periodontal treatment

Study summary

To compare the effect of non-invasive injectable PRF application on periodontal healing in Grade 2-3 endodontic periodontal lesions.

Hypothesis: No difference in healing outcome between the two groups. Outcome measure 1: (Primary outcome)

Periodontal healing as demonstrated by change in Clinical Attachment Level (CAL)

Secondary outcomes:

* Change in Pocket probing depth (PPD)
* Radiographic defect fill at 6 months using digital periapical radiographs compared to baseline.
* Gingival recession
* Tooth mobility
* Bleeding on Probing (BoP)
* Plaque index
* Patient reported outcomes (VAS pain scores)
* Number of analgesics consumed
* Cost of treatment
* Quality of life questionnaire

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: Presence of a periodontal-endodontic lesion (EPL without root damage in non-periodontitis patients) according to (Herrera et al., 2018) confirmed by: * A negative response to pulp sensibility test * Deep periodontal pockets (≥5 mm) reaching or close to the apex (EPL Grade 2 or 3) according to the classification by (Herrera et al., 2018). * Absence of root damage Exclusion Criteria: * • Presence of one narrow deep periodontal pocket around the affected tooth (EPL Grade 1) * Presence of any type of root damage such as root fracture, perforation or resorption * Presence of crowns or fixed prosthesis * History of fractured teeth * Occlusal abnormality * Periodontal therapy for the last 3 months * Presence of systemic diseases affecting periodontal healing * Smoking

Primary outcome measure(s)

  • Clinical Attachment Level — 6 months
    Periodontal parameters will be measured using UNC periodontal probe

Trial sites (1)

FacilityCityRegionStatus
Faculty of Dentistry, Cairo University Cairo Cairo Governorate

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07928856 on ClinicalTrials.gov ↗ ← All trials in Egypt