Clinical Efficacy of a Natural Biopolymer-Based Irrigant

Condition(s) studied

Investigational drug(s) / intervention(s)

Chitosan Nanoparticles: To evaluate the incidence and intensity of postoperative pain and acute exacerbations following root canal debridement using Apical Negative Pressure-mediated Chitosan nanoparticles versus Sodium Hypochlorite.

Study summary

One primary objective in the root canal treatments is to ensure chemo mechanical removal of microorganisms and organic/inorganic tissue residues from the infected root canals. Studies in the literature report that due to the structure of the root canals, mechanical instrumentation alone could not perform a satisfying cleaning in the canal. some areas have remained unreached and infected, thus irrigation has played a key role in the achievement of root canal treatments.

Eligibility

Primary outcome measure(s)

• Post Operative Pain — 7 days
  Assessment of the participants after the treatment from pain using numerical rating scale (NRS) to record their assessment of pain after (12) hours, then every day up to 7 days.Patients will be instructed to attribute a value to their perceived pain based on the NRS, which is a pain screening tool, commonly used to assess pain severity at that moment in time using a 0-10 scale, with zero meaning "no pain" and 10 meaning "the worst pain.

Trial sites (1)

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