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Clinical Trials in Egypt / NCT07876973
Recruiting Phase 3

Treatment of Class II Mandibular Furcation Defects

NCT07876973 · tracked via the Priya Life Science Egypt tracker
Sponsor
Cairo University
Phase
Phase 3
Started
2026-11
Last updated
2026-10-15

Condition(s) studied

Class II Furcation Defect

Investigational drug(s) / intervention(s)

Injectable-PRF (I-PRF) →sticky bone (I-PRF+Xenograft) →

Injectable-PRF (I-PRF): I-PRF will be prepared as follows: (Choukran et al., 2018) i-PRF was prepared by Choukroun's method. A total of 10 mL of venous blood was withdrawn from the patient and was immediately centrifuged for 3 min at 700 rpm in the centrifuge. The liquid in the top of the tube is obtained after centrifugation was collected using a blunt ended syringe. A limited amount of i-PRF was obtained from 10 mL of blood sample (1mL approximately). The injectable platelet rich fibrin will be injected into the defect Microsurgical suturing technique with 5or 6-0 monofilament polypropylene suture materials will be performed for optimal wound closure of the surgical area.

sticky bone (I-PRF+Xenograft): The xenograft will be obtained and mixed with i-PRF. Mixing of xenograft and injectable platelet rich fibrin to get sticky bone graft that will be easily placed into the defect. The flap will approximated and Microsurgical suturing technique with 5or 6-0 monofilament polypropylene suture materials will be performed for optimal wound closure of the surgical area.

Study summary

The aim of this study is to investigate the clinical efficiency and radiographic outcomes following minimally invasive surgical technique with xenograft and i-PRF versus i-PRF in the management of class II furcation defects in mandibular molars

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Patients with healthy systemic condition * Adult patients (18 years old and older) * Patients with stage lll or IV periodontitis. * Patients having a buccal or lingual degree II A or B furcation defect in periapical-lesion free and not mobile first or second mandibular molars with horizontal attachment loss HCAL \>3 mm and probing depth PD ≥5 mm in the mid-buccal or mid-lingual sites when evaluated 12 weeks after non-surgical periodontal therapy. * Patients with full mouth plaque score\<10% on the day of the surgery. * Patients with full mouth bleeding score\<10% on the day of the surgery. * Compliance with good oral hygiene. * Patients accept 12-months follow-up period (cooperative patients). * Patients provide an informed consent. Exclusion Criteria: * Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis. * Defects that involve the buccal and lingual sites. * Smokers ˃ 10 cigarettes / day * Pregnant and lactating female

Primary outcome measure(s)

  • difference in probing depth — at baseline,6 months,12 months follow up
    It is measured in milimeters using UNC 15 periodontal probe that inserted in the buccal gingival sulcus in the area corresponding to the furcation defect with a force not exceed 25 g

Trial sites (1)

FacilityCityRegionStatus
Faculty of Dentistry,Cairo University Cairo Cairo Governorate Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07876973 on ClinicalTrials.gov ↗ ← All trials in Egypt