Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Recruiting Not applicable

Calcium Gluconate Activated in Anterior Disc Displacement With Reduction of the Temporomandibular Joint

NCT07855887 · tracked via the Priya Life Science Egypt tracker
Phase
Not applicable
Started
2026-07-25
Last updated
2026-10-02

Condition(s) studied

Temporomandibular Joint Disorders

Investigational drug(s) / intervention(s)

activated platelet-rich plasmanon-activated platelet-rich plasma

activated platelet-rich plasma: Intra-articular retrodiscal injection of autologous platelet-rich plasma (PRP) activated with 0.5 milliliters of 10% sterile calcium gluconate per 5 milliliters of prepared PRP, administered as a single anatomical landmark-guided injection into the retrodiscal tissue.

non-activated platelet-rich plasma: Intra-articular retrodiscal injection of autologous non-activated platelet-rich plasma, prepared using identical double-centrifugation technique and administered using identical injection protocol and volume

Study summary

To compare the efficacy of retro discal injection of calcium gluconate-activated PRP versus non-activated PRP in adults with Anterior Disc Displacement with Reduction (ADDWR). Efficacy will be measured by the reduction of symptoms and the restoration of function, specifically targeting the normal Maximum Mouth Opening (MMO) range

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Adults aged 18-65 years. * Clinical and MRI diagnosis of ADDWR per DCTMD criteria. * Baseline VAS pain score 4-10. * Failure of at least 2 conservative treatments (splint therapy, physiotherapy, NSAIDs) for 3 months. * Written informed consent. Exclusion Criteria: * • Systemic inflammatory arthritis (Rheumatoid arthritis, etc.). * Recent TMJ surgery or intra-articular injection within the last 6 months. * Pregnancy or lactation. * Active TMJ infection or malignancy. * Coagulopathy or anticoagulant therapy. * Contraindications to MRI (e.g., pacemaker).

Primary outcome measure(s)

  • Maximal Interincisal Opening (MIO) — 3 months
    measuring in millimeters using ruler

Trial sites (1)

FacilityCityRegionStatus
Cairo University Cairo Egypt Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07855887 on ClinicalTrials.gov ↗ ← All trials in Egypt