Smart Scaffolds, Stronger Smiles Smarter Healing: AI-Boosted Multiphasic Scaffold Design for PDL Regeneration

Condition(s) studied

Investigational drug(s) / intervention(s)

AI algorithms generated a 3D multiphasic, graded lattice structure: Patients underwent minimally invasive surgical intervention. Following preoperative diagnosis of severe infrabony defects exhibiting mobility and loss of periodontal support, a minimally invasive flap was elevated, and the defect was thoroughly debrided and prepared. The custom-printed multiphasic scaffold was seated into the defect with precision to ensure stability, and complete primary flap closure was achieved \[

Study summary

The periodontal ligament is vital for tooth support, and its loss, frequently resulting from periodontitis, trauma, or endodontic lesions, presents a significant clinical challenge; global cases of severe periodontitis increased by 91.54% from 1990 to 2021. Conventional monophasic scaffolds offer a uniform environment, limiting their efficacy in regenerating complex, multi-tissue structures like the periodontium. This study introduces an AI-enhanced, 3D multi-phasic scaffold to precisely restore the periodontal apparatus and overcome the limitations of non-uniform tissue growth seen in some multiphasic designs. The methodology involved sequential steps: high-resolution CBCT and intraoral scans to capture defect geometry; precise defect mapping to define the Target Regeneration Volume; and AI Mesh mixer implementation to generate three distinct, seamlessly graded lattice zones. This AI-driven design ensures Optimal Biomechanics (Precision) by perfectly matching the scaffold's stiffness to native tissue, thereby eliminating stress-shielding.

Eligibility

Primary outcome measure(s)

• Probing Depth — 12 months
  the measured distance from the edge of the gum (gingival margin) to the bottom of the gum pocket or sulcus.
• Bone quality , PDL formation — 2,6,12 month
  refers to the density and architectural composition of the jawbone, which determines its strength and ability to stabilize a dental implant

Trial sites (1)

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