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Clinical Trials in Egypt / NCT07709286
Recruiting Phase 1

Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion

NCT07709286 · tracked via the Priya Life Science Egypt tracker
Phase
Phase 1
Started
2026-01-10
Last updated
2026-07-16

Condition(s) studied

Teeth Staining

Investigational drug(s) / intervention(s)

(Antivet, MDC DENTAL, Zapopan Jalisco México)Opalustrephosphoric acid 37% and aluminium oxid 50 microns

(Antivet, MDC DENTAL, Zapopan Jalisco México): specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \<3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be cleansed without damaging it

Opalustre: technique involves employing a mixture 6.6% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities for 60 seconds. The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result. .

phosphoric acid 37% and aluminium oxid 50 microns: ● Equal quantities from phosphoric acid 37% and aluminium oxid 50 microns will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications.

Study summary

This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth.

Eligibility

Sex
ALL
Min age
16 Years
Max age
50 Years
Healthy volunteers
No
1. Eligibility Criteria of participants: Inclusion Criteria: * Patients with moderate to mild stained teeth. * 16-50 years. * Males or Females. * Co-operative patients approving to participate in the study. Exclusion Criteria: * High caries index with poor oral hygiene. * Severe medical complications. * Pregnancy. * Xerostomia. * Lack of compliance. * Smokers 2. Eligibility Criteria of teeth: Inclusion Criteria of teeth: * Anterior teeth. * Mild to moderate intrinsic or extrinsic stains. * Vital and non-sensitive anterior teeth. Exclusion criteria of the teeth: * pitted enamel. * carious teeth. * Deep lesions. * Severe periodontal problems. * Previous treatment for the stained teeth

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Egyptian Russian University Badr Cairo Governorate Recruiting

More Misr University for Science and Technology trials in Egypt

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07709286 on ClinicalTrials.gov ↗ ← All trials in Egypt