cardiac sympathetic denervationStandard open-heart surgery without additional epicardial or fat pad dissection.
cardiac sympathetic denervation: Before CPB initiation or during aortic cross-clamping, surgical denervation will be performed via meticulous blunt and sharp dissection. Target sites include \[e.g., complete transection/resection of the ligament of Marshall, fat pad mobilization at Waterston's groove, and epicardial neural pathway division\].
Standard open-heart surgery without additional epicardial or fat pad dissection.: Standard open-heart surgery without additional epicardial or fat pad dissection.
Study summary
we compare the effect of cutting heart nerves in one group of patients with open heart surgery and other group without cutting oh development of disturbance of heart beat after surgery
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria:
Age ≥18 years scheduled for elective open-heart surgery via median sternotomy (CABG, valve repair/replacement, or combined procedures).
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Exclusion Criteria:
* Preoperative permanent pacemaker or ICD.
* Emergency surgery, active endocarditis, or severe hemodynamic instability.
* Concomitant planned surgical ablation (e.g., Cox-Maze procedure) or left atrial appendage occlusion.
* Preoperative use of antiarrhythmic drugs (AADs) other than beta-blockers within 5 half-lives of surgery.
Primary outcome measure(s)
Incidence of overall Post operative atrial fibrillation — 7th Post operative day or hospital discharge (whichever comes first). defined as any telemetry-documented or 12-lead ECG-confirmed episode of atrial fibrillation, atrial flutter, or atrial tachycardia lasting ≥30 continuous seconds through POD 7 or hospital discharge defined as any telemetry-documented or 12-lead ECG-confirmed episode of atrial fibrillation, atrial flutter, or atrial tachycardia lasting ≥30 continuous seconds through POD 7 or hospital discharge (whichever comes first
Incidence of persistent Post operative atrial fibrillation — 3 months posoperative (duration \>24 continuous hours or requiring urgent chemical/electrical cardioversion due to hemodynamic instability).
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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