Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession

Condition(s) studied

Investigational drug(s) / intervention(s)

Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides: A coronally advanced flap will be performed with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing

Study summary

This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession. Twelve patients will be included and followed for 6 months. Clinical outcomes will include percentage of root coverage, clinical attachment level gain, gingival thickness, probing depth, width of keratinized tissue, post-operative pain, and patient aesthetic satisfaction.

Eligibility

Primary outcome measure(s)

• Percentage of Root Coverage — Baseline, 1 month, 3 months, and 6 months
  Percentage of root coverage will be calculated using the following formula: (Initial Recession Depth - Post-Treatment Recession Depth) / Initial Recession Depth × 100.
• Clinical Attachment Level (CAL) Gain — Baseline, 3 months, and 6 months
  Clinical attachment level will be measured in millimetres using a UNC-15 periodontal probe

Trial sites (1)

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