Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension

Condition(s) studied

Investigational drug(s) / intervention(s)

Normal Saline: four 10-mL syringes of normal saline, The patient will receive the first dose of the intervention with induction (0.1 ml/kg). After induction of anesthesia, the study drug will be given every 5 min for 20 min and will be withheld if MAP was ≥80 mmHg or if any vasopressor is given within 2 min of the current scheduled dose

Ephedrine: four 10-mL syringes of ephedrine 1 mg/mL. The patient will receive the first dose of the intervention with induction (0.1 ml/kg). After induction of anesthesia, the study drug will be given every 5 min for 20 min and will be withheld if MAP was ≥80 mmHg or if any vasopressor is given within 2 min of the current scheduled dose.

Study summary

The aim of this work is to assess the efficacy of intermittent ephedrine boluses in prophylaxis against postinduction hypotension in high-risk patients undergoing major abdominal surgery, compared to standard care.

Eligibility

Primary outcome measure(s)

• incidence of postinduction hypotension — from induction of anesthesia until 20 minutes after induction
  mean arterial pressure \< 65 mmHg

Trial sites (1)

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