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Clinical Trials in Egypt / NCT07600099
Starting soon Not applicable

Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth.

NCT07600099 · tracked via the Priya Life Science Egypt tracker
Sponsor
Cairo University
Phase
Not applicable
Started
2026-09-01
Last updated
2026-05-20

Condition(s) studied

Dental PainFacial Swelling

Investigational drug(s) / intervention(s)

Resin sealer with conventional gutta percha.Bioceramic sealer with bioceramic gutta-percha.

Resin sealer with conventional gutta percha.: It is the gold standard obturation technique which will be used as the control group.

Bioceramic sealer with bioceramic gutta-percha.: Bioceramic sealer and bioceramic gutta-percha creating a monoblock for obturation of root canals.

Study summary

A randomized clinical trial will compare two root canal filling approaches in necrotic single-rooted teeth. The test group will receive bioceramic mono-block obturation using bioceramic nano-coated gutta-percha with a bioceramic sealer, while the control group will receive traditional gutta-percha with a resin-based sealer. The main aim is to determine whether the bioceramic system can reduce postoperative pain and swelling within 48 hours after treatment compared with the conventional method. Patients aged 20-55 years who have necrotic single-rooted teeth and meet specific clinical and radiographic criteria will be recruited from the outpatient clinics of the Faculty of Dentistry, Cairo University.

Postoperative pain will be measured using a visual analogue scale, and swelling will be assessed using a standardized swelling score at 24 and 48 hours. The study hypothesizes that the bioceramic mono-block technique, due to its improved sealing ability and bioactivity, may lead to less postoperative discomfort and better early clinical outcomes than the gold-standard resin-sealer technique. The findings are expected to provide evidence to guide clinicians on whether adopting bioceramic nano-enhanced obturation can improve patient-centered outcomes after root canal treatment.

Eligibility

Sex
ALL
Min age
20 Years
Max age
55 Years
Healthy volunteers
Accepted
Inclusion Criteria: Patients aged 20-55 years. Patients with good oral hygiene, free of calculus, and with a probing depth not exceeding 2-3 mm. Necrotic single-rooted, single-canal permanent teeth with or without periapical lesions. If lesion is present, ranging from 2-5 mm in size. Absence of swelling. Medically free patients. Exclusion Criteria: Patients with poor oral hygiene. Vital teeth. Necrotic teeth without periapical lesions. Primary teeth. Complex root morphology other than Type I. Internal or external root resorption. Vertical root fractures. Cracked teeth. Intraoral or extraoral swelling.

Primary outcome measure(s)

  • Postoperative pain assessed by using a 10 cm Visual Analogue Scale. — 48 hours
    Pain will be assessed using a 10 cm Visual analogue Scale from 0-10, where 0 indicates no pain, 1-3 Mild pain, 4-6 Moderate Pain and 7-10 Sever pain. Participants will be asked to verbally report their pain score after 24 hours and 48 hours.

Trial sites (1)

FacilityCityRegionStatus
Out patient clinic Faculty of Dentistry Cairo University Cairo Cairo Governorate

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07600099 on ClinicalTrials.gov ↗ ← All trials in Egypt