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Clinical Trials in Egypt / NCT07599397
Starting soon Early Phase 1

Evaluation of the Changes in Matrix Metalloproteinase-9 Levels With Salvadora Persica (Miswak) in Periodontal Fibroblasts and Gingival Crevicular Fluid in Patients With Periodontitis

NCT07599397 · tracked via the Priya Life Science Egypt tracker
Sponsor
Cairo University
Phase
Early Phase 1
Started
2026-06-01
Last updated
2026-05-20

Condition(s) studied

Stage II or Stage III Grade B Periodontitis

Investigational drug(s) / intervention(s)

Salvadora Persica RootToothbrushing

Salvadora Persica Root: Miswak chewing sticks will be used as an alternative to the toothbrush

Toothbrushing: Modified Bass technique will be employed

Study summary

The study is conducted to evaluate the invitro effect of Salvadora persica (miswak) extract on periodontal fibroblasts production of matrix metalloproteinase-9 (MMP-9) and prostaglandin E2 (PGE2) and correlating the results to clinical outcomes and biomarkers by assessing the MMP-9 and PGE2 levels in gingival crevicular fluid by a randomized controlled clinical trial comparing the use of toothbrush as the control group with miswak chewing stick as a substitute to personal mechanical plaque control in patients with stage II or III grade B periodontitis.

Eligibility

Sex
ALL
Min age
20 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria: * Stage II or III, grade B periodontitis Exclusion Criteria: * Have poor manual dexterity * Systemic condition that may affect healing * Administration of certain medications that may modify the outcomes * Smoking patients * Pregnant females * Periapical involvement in teeth * Habitual or experienced users of miswak chewing sticks * History of topical or systemic chemical plaque control during the past 6 months * History of periodontal surgery during the past 6 months * Local risk factor that interfere with accessibility for regular personal plaque control aids

Primary outcome measure(s)

  • Matrix metalloproteinase-9 (MMP-9) level in gingival crevicular fluid (GCF) — 3 months
    GCF will be collected at baseline and after 3 months to assess the MMP-9 level change by ELISA kit

Trial sites (1)

FacilityCityRegionStatus
Ahram Canadian University Giza Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07599397 on ClinicalTrials.gov ↗ ← All trials in Egypt