Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide
Clinical Trials in Egypt / NCT07394842
Active, not recruiting Observational

Longitudinal Oral Health Changes After Head and Neck Radiotherapy

NCT07394842 · tracked via the Priya Life Science Egypt tracker
Sponsor
Ain Shams University
Phase
Observational
Started
2025-02-01
Last updated
2026-02-06

Condition(s) studied

Head & Neck CancerHead & Neck Squamous Cell CarcinomaPeriodontal DiseaseXerostomia

Study summary

This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple post-treatment visits. Changes in periodontal health, dental status, salivary function, and patient-reported oral health quality of life are assessed. The study aims to better understand the long-term oral complications of radiotherapy and to support improved preventive and supportive dental care for cancer patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥18 years * Histologically confirmed head and neck malignancy * Planned radiotherapy dose ≥50 Gy * Presence of at least 20 natural teeth * No periodontal treatment during the preceding 6 months * Ability to comply with the scheduled follow-up visits Exclusion Criteria: * Previous head and neck radiotherapy * Autoimmune salivary gland disorders * Current bisphosphonate or anti-resorptive therapy * Pregnancy * Uncontrolled systemic disease (HbA1c \>9% for diabetic patients) * Severe periodontal destruction requiring immediate surgical intervention

Primary outcome measure(s)

  • Change in Clinical Attachment Level (CAL) — Baseline, end of radiotherapy, and 3, 6, 9, and 12 months post-radiotherapy
    Mean change in clinical attachment level measured in millimeters using a standardized UNC-15 periodontal probe at six sites per tooth. CAL is used as the primary indicator of periodontal tissue loss following radiotherapy.

Trial sites (1)

FacilityCityRegionStatus
Ahmed Maher Teaching Hospital Cairo Egypt

More Ain Shams University trials in Egypt

Peripheral Perfusion Index as an Early Predictor of Successful Caudal Block in Pediatric Patients Undergoing Lower Abdominopelvic Surgeries Under General Anesthesia Recruiting
Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery Recruiting
Chamomile Gummies and Pediatric Dental Anxiety Starting soon
Comparison Between Ultrasound Guided Pericapsular Nerve Block And Suprainguinal Fascia Iliaca Nerve Block in Hip Surgery Recruiting
Comparative Study Between Conventional Radiofrequency Ablation vs Chemical Neurolysis of Ganglion Impar for Treatment of Chronic Non Cancer Related Coccydynia Active, not recruiting

Other trials for the same condition

Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis Recruiting
Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial Enrolling by invitation
Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique Active, not recruiting
Evaluation of Hyaluronic Acid and Chlorhexidine Gel as an Adjunct to Minimally Invasive Non-surgical Therapy in the Treatment of Stage III and IV Periodontitis Active, not recruiting
Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07394842 on ClinicalTrials.gov ↗ ← All trials in Egypt