Head & Neck CancerHead & Neck Squamous Cell CarcinomaPeriodontal DiseaseXerostomia
Study summary
This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple post-treatment visits. Changes in periodontal health, dental status, salivary function, and patient-reported oral health quality of life are assessed. The study aims to better understand the long-term oral complications of radiotherapy and to support improved preventive and supportive dental care for cancer patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥18 years
* Histologically confirmed head and neck malignancy
* Planned radiotherapy dose ≥50 Gy
* Presence of at least 20 natural teeth
* No periodontal treatment during the preceding 6 months
* Ability to comply with the scheduled follow-up visits
Exclusion Criteria:
* Previous head and neck radiotherapy
* Autoimmune salivary gland disorders
* Current bisphosphonate or anti-resorptive therapy
* Pregnancy
* Uncontrolled systemic disease (HbA1c \>9% for diabetic patients)
* Severe periodontal destruction requiring immediate surgical intervention
Primary outcome measure(s)
Change in Clinical Attachment Level (CAL) — Baseline, end of radiotherapy, and 3, 6, 9, and 12 months post-radiotherapy Mean change in clinical attachment level measured in millimeters using a standardized UNC-15 periodontal probe at six sites per tooth. CAL is used as the primary indicator of periodontal tissue loss following radiotherapy.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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