Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Clinical Trials in Egypt / NCT07357233
Recruiting Not applicable

Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides

NCT07357233 · tracked via the Priya Life Science Egypt tracker
Sponsor
Alexandria University
Phase
Not applicable
Started
2025-09-01
Last updated
2026-01-21

Condition(s) studied

Post Operative Pain

Investigational drug(s) / intervention(s)

Manual-lessConventional technique

Manual-less: Canals preparation with rotary dota files escaping scouting and glide path step

Conventional technique: Canal preparation with rotary drill files, with prior scouting and glide path with hand files.

Study summary

General aim: assessment of post operative pain and time of preparation with the execution of manual-less technique and conventional technique.

Specific aim: correlation between post operative pain and release of Substance P and Calcitonin gene-related peptide.

Eligibility

Sex
ALL
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Patients with symptomatic irreversible pulpitis and apical periodontitis in mandibular molars with closed apex.(17) 2. Healthy males and females (Category: American Society of Anesthesiologists class I). 3. Age of patients range from 18 to 50 years old. 4. Those who could understand the use of the numeric rating scale (NRS) for pain. 5. In cases where radiographs show no root resorption or abnormal anatomy. 6. Patients with good oral hygiene and free from periodontal diseases. Exclusion Criteria: 1. Allergy to anesthetics. 2. Pregnancy 3. Unrestorable teeth. 4. Patient on analgesics. 5. Prescence of root resorption or abnormal anatomy.

Primary outcome measure(s)

  • Change in post operative pain — 6 hours,12 hours,24 hours,48 hours,72 hours
    Numeric rating scale ranges from zero to 10. zero means no pain and 10 means severe pain.

Trial sites (1)

FacilityCityRegionStatus
Alexandria Faculty of Dentistry Alexandria Egypt Recruiting

More Alexandria University trials in Egypt

Computer Guided Single Needle Arthrocentesis Active, not recruiting
Effect of Husband Attendance on Anesthesia Performance and Maternal-Neonatal Outcomes During Elective Cesarean Section Under Spinal Anesthesia Enrolling by invitation
Quality of Recovery in Laparoscopic Sleeve Gastrectomy Using Dexmedetomidine Infusion Versus Laparoscopic TAP Block in Combination With Paragastric Neural Block Recruiting
The Prophylactic Effect of Garlic Tablets to Prevent Nosocomial Infections in Intensive Care Unit Patients. Enrolling by invitation
Two Treatment Modalities for Myogenous Temporomandibular Disorders Recruiting

Other trials for the same condition

The Analgesic Efficacy of M-TAPA for Laparoscopic Abdominal Surgery in Children Recruiting
Analgesic Efficacy of Different Nerve Blocks in Postoperative Cesarean Section Recruiting
Recycling of Three Pressable Ceramics With Different Weight Percentage Active, not recruiting
Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions Recruiting
Impact of a New Bioceramic Based Intracanal Medication Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07357233 on ClinicalTrials.gov ↗ ← All trials in Egypt