Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment
Condition(s) studied
Investigational drug(s) / intervention(s)
Coenzyme Q10 gel: Application will be performed 2-3 times daily for 4 weeks.
Topical curcumin gel: Application will be performed 2-3 times daily for 4 weeks.
Study summary
Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.
Eligibility
Primary outcome measure(s)
- Change in lesion size — baseline, 4 weeks, and 12 weeks
measured clinically with a periodontal probe and/or digital images
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt | Alexandria | Egypt | Recruiting |
More Alexandria University trials in Egypt
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07331935 on ClinicalTrials.gov ↗ ← All trials in Egypt