Evaluation Study of Retro Discal Tissue Injection Arthroscopically Versus Ultrasound Guide Injection

NCT07316790 · tracked via the Priya Life Science Egypt tracker

Sponsor

Cairo University

Phase

Not applicable

Started

2025-12-13

Last updated

2026-01-05

Condition(s) studied

Arthroscope

Investigational drug(s) / intervention(s)

Arthroscopic retrodiscal tissue injectionUltrasound-guided retrodiscal tissue injection

Arthroscopic retrodiscal tissue injection: Arthroscopic retrodiscal tissue injection

Ultrasound-guided retrodiscal tissue injection: Ultrasound-guided retrodiscal tissue injection

Study summary

A comparative evaluation study of arthroscopic retrodiscal tissue injection versus ultrasound-guided injection in temporomandibular joint disorders aims to assess differences in pain relief, functional improvement, and clinical outcomes between an invasive and a minimally invasive delivery technique. Arthroscopic injection allows direct visualization of intra-articular structures, accurate targeting of the retrodiscal tissues, and simultaneous management of associated pathology such as synovitis or adhesions, which may enhance therapeutic outcomes in advanced internal derangement. In contrast, ultrasound-guided injection offers a less invasive, cost-effective, and outpatient-based approach with improved accuracy over blind techniques, making it suitable for early or moderate cases. While both methods are effective in reducing pain and improving mouth opening and jaw function, arthroscopic injection may provide superior results in patients requiring diagnostic confirmation and mechanical intervention, whereas ultrasound-guided injection offers comparable symptomatic improvement with lower procedural morbidity and resource utilization.

Eligibility

Sex

ALL

Min age

15 Years

Max age

70 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Adults aged 18-60 years with symptomatic TMJ disorder/internal derangement (unilateral or bilateral) * TMJ pain at rest and/or during function for ≥ 3 months * Clinical diagnosis consistent with disc displacement with or without reduction (with or without MRI confirmation, if included in the protocol) * Baseline pain intensity ≥ 4/10 on VAS or NRS * Limitation of mouth opening or functional impairment (e.g., maximum mouth opening ≤ 35 mm or pain-related limitation) * Failed or insufficient response to conservative therapy for ≥ 4-6 weeks (e.g., soft diet, NSAIDs, splint therapy, physiotherapy) * Ability to provide informed consent and comply with scheduled follow-up visits Exclusion Criteria: * Previous TMJ surgery (arthroscopy or arthrotomy) on the study side or TMJ injection within the last 3-6 months * TMJ ankylosis, fracture, tumor, or active infection * Primary inflammatory arthropathy (e.g., rheumatoid arthritis, gout, psoriatic arthritis) or systemic connective tissue disease affecting the TMJ * Significant degenerative joint disease (advanced osteoarthritis) if the study focuses on internal derangement or soft tissue pathology * Severe skeletal or dentofacial deformity requiring orthognathic surgery during the study period * Pregnancy or lactation * Bleeding disorders, platelet disorders, or anticoagulant therapy that cannot be safely managed (particularly relevant for PRP injections) * Known allergy or contraindication to the planned injectate or local anesthetic * Severe uncontrolled systemic disease (ASA III-IV) or inability to tolerate anesthesia or sedation (for arthroscopy arm) * Active psychiatric or neurologic condition that may impair accurate pain reporting or follow-up compliance

Primary outcome measure(s)

Pain intensity (VAS) — Baseline → 2 months (early outcome) Baseline → 6 months (mid-term outcome)
Change in TMJ pain score measured on a 10-cm Visual Analogue Scale (0 = no pain, 10 = worst pain) from baseline to 3 months post-intervention.

Trial sites (1)

Facility	City	Region	Status
facility of Dentistry	Cairo	Old Cairo

More Cairo University trials in Egypt

Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth Recruiting

Effect of Thoracic Mobilization in People With Central Obesity Active, not recruiting

Transanal vs Transvaginal Rectal Resection for Anterior Rectocele Recruiting

The Association Between Abdominal Obesity, Gluteal Muscles Strength and Endurance in Young and Middle-aged Adults. Active, not recruiting

Relationship Between Facial Palsy and Psychological Distress Starting soon

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07316790 on ClinicalTrials.gov ↗ ← All trials in Egypt