Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Clinical Trials in Egypt / NCT07316582
Enrolling by invitation Phase 4

Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis

NCT07316582 · tracked via the Priya Life Science Egypt tracker
Sponsor
Al-Azhar University
Phase
Phase 4
Started
2025-11-01
Last updated
2026-01-05

Condition(s) studied

Periodontitis Stage II

Investigational drug(s) / intervention(s)

Melatonin-Loaded Injectable Platelet-Rich Fibrininjectible platelet rich fibrin (i-PRF ) →

Melatonin-Loaded Injectable Platelet-Rich Fibrin: patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection

injectible platelet rich fibrin (i-PRF ): patients will be included in this group receiving (SRP) with local application of i-PRF

Study summary

melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis

Eligibility

Sex
ALL
Min age
20 Years
Max age
60 Years
Healthy volunteers
Accepted
Inclusion Criteria: \- Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification • Minimum of two non-adjacent periodontal pockets \<5 mm in different quadrants • Systemically healthy individuals willing to participate and comply with follow-up visits • Radiographic bone loss (ranged from is 10-20% mostly horizontal Exclusion Criteria: History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis) • Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months • Smoking or tobacco use • Pregnancy or lactation • Allergy to melatonin or related compounds \-

Primary outcome measure(s)

  • Clinical attachment level (CAL) — 6 months

Trial sites (1)

FacilityCityRegionStatus
Faculty of Dental Medicine for girls Al-Azhar University New Cairo Egypt

More Al-Azhar University trials in Egypt

Evaluation of Different Attachments on Implant-Retained Mandibular Overdenture. Recruiting
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth Starting soon
Ultrasound-Guided Microwave Ablation for Breast Fibroadenoma: Safety and Cosmetic Outcomes Starting soon
Laboratory and Ultrasound Findings and Response to Letrozole in PCOS Patients Starting soon
Artificial Intelligence for the Diagnosis of Gingivitis Active, not recruiting

Other trials for the same condition

"Comparison of Spirulina Gels for Treating Stage II Grade B Periodontitis" Enrolling by invitation
Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07316582 on ClinicalTrials.gov ↗ ← All trials in Egypt