N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis

Condition(s) studied

Investigational drug(s) / intervention(s)

Calcium hydroxide (Ca(OH)₂): UltraCal XS calcium hydroxide (Ca(OH)₂) intracanal medication for 7 days

N-Acetylcysteine (NAC): N-acetylcysteine (NAC) intracanal medication for 7 days and 600 mg/day oral NAC for 21 days

Study summary

A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.

Eligibility

Primary outcome measure(s)

• Postoperative pain intensity — Pain will be recorded before the intervention, and patients will use the Numerical Rating Scale (NRS) to self-assess postoperative pain at 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, and 1 week.
  Postoperative pain will be assessed using the Numerical Rating Scale (NRS), which is a scale from 0 (no pain) to 10 (worst pain imaginable). Patients will be asked to choose the number that represents their pain intensity. Pain level will be assigned as follows: 0, "no pain"; 1-3, "mild pain"; 4-6, "moderate pain"; 7-10, "severe pain."
• Assessment of periapical healing — A CBCT scan will be taken preoperatively and at six months follow-up.
  Assessment of the percentage change in lesion volume through three-dimensional (3D) reconstruction of the lesions in Cone beam computed tomographic (CBCT) scans performed preoperatively and after a six-month follow-up.

Trial sites (1)

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