Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds

Inclusion Criteria: * ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease. * Age between 15-40 years. * Males \& Females. * Patients' acceptance to participate in the trial. * Patients who can understand pain scale and can sign the informed consent (Appendix I). * Mature mandibular fist molars: * Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue. * Giving a positive response to pulp sensitivity testing. * Having negative response to percussion. * Having normal radiographic appearance of periapical tissues. * Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation. Exclusion Criteria: * Pregnant and lactating females. * Patients with physical or mental handicapping conditions. * Patients unwilling to participate in a 12-months follow up. * Mandibular first molars with: * Immature roots. * Negative response to pulp sensitivity testing. * Positive response to percussion. * Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification. * Intraoral swelling or fistula. * Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.