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Recruiting Observational

Sciatic Nerve Stiffness Using Two-Sequences of Lower Limb Neurodynamic Testing: A Shear Wave Elastography Study

NCT07136441 · tracked via the Priya Life Science Egypt tracker
Phase
Observational
Started
2025-08-15
Last updated
2025-09-11

Condition(s) studied

Sciatic Nerve

Investigational drug(s) / intervention(s)

Lower Limb Neurodynamic Test (LLNT) with Shear Wave Elastography

Lower Limb Neurodynamic Test (LLNT) with Shear Wave Elastography: Participants underwent sciatic nerve stiffness assessment using shear wave elastography during two distinct sequences of the lower limb neurodynamic test. Each participant received: Proximal-to-distal sequence: Starting with hip flexion, followed by knee extension, then ankle dorsiflexion with toe extension. Distal-to-proximal sequence: Starting with ankle dorsiflexion and toe extension, followed by knee extension, then hip flexion.

Study summary

The purposes of the study are:

1. To measure differences in Sciatic nerve (SN) stiffness using shear-wave elastography (SWE) during two movement sequences of the lower limb neurodynamic test (LLNT) in low back pain with sciatica.
2. To measure differences in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test in control group.
3. To compare difference in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test between low back pain patients with sciatica and control group.

Eligibility

Sex
ALL
Min age
25 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Thirty participants ranging in age from 25 to 40 years from both genders with a diagnosis of low back pain with radiating leg pain and thirty control group. * The main symptoms are low back pain with unilateral leg pain(sciatica) for 3-12 months for group A. * Patients with lumbar disc herniation (L4-5) with diagnostic imaging as MRI for group A. * Positive straight leg raising are considered for inclusion in the study for group A. * Control group must be free from any symptoms of nerve irritation or compression, with normal neurological examination findings, including reflexes, sensation, negative straight leg raising and motor strength. Exclusion Criteria: * Diabetes mellitus. * Any type of polyneuropathy * Trauma of lumbar spine * Previous history of back surgery * Piriformis syndrome. * Participants with conditions that reduce image quality on US imaging (thick gluteal subcutaneous fat tissue. * Hip joint prosthesis. * Professional athletes (Neto et al., 2024). * Skin infection

Primary outcome measure(s)

  • Shear Wave Velocity (SWV) measured in meters per second (m/s) — 20 minutes, During a single assessment session at baseline
    Quantitative measurement of sciatic nerve stiffness during two different movement sequences of the Lower Limb Neurodynamic Test (LLNT). Higher SWV values indicate increased nerve stiffness.

Trial sites (1)

FacilityCityRegionStatus
Cairo University Giza Egypt Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07136441 on ClinicalTrials.gov ↗ ← All trials in Egypt