Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes

Condition(s) studied

Investigational drug(s) / intervention(s)

Insulin producing stem cells infusion: 1. Liposuction of the anterior abdominal subcutaneous fat layer of participant 2. Characterization and Identification of mesenchymal stem cells 3. Differentiation of mesenchymal stem cells into insulin producing stem cells 4. In vitro detection of Insulin and c-peptide in differentiated MSC (Confirmatory tests for the insulin producing cells) 5. In vitro Insulin and c-peptide release detection in differentiated MSC in response to increasing glucose concentrations Differentiated MSCs injection in human subjects 6. Followup

Study summary

Type 1 Diabetes is a chronic autoimmune disease. It results from autoimmune destruction of pancreatic Beta cells leading to absolute insulin insufficiency. The establishment of pluripotent like human stem cells derived from adipose tissue derived mesenchymal cell origin have introduced a new potential source for cell therapy in type 1 diabetic patients, especially in light of recent successes in producing glucose-sensitive insulin secreting cells and this will be the scope of this study. In the last decade, human clinical trials of introducing insulin producing stem cells from various origins were approved and conducted.

Eligibility

Primary outcome measure(s)

• Insulin producing mesenchymal stem cells efficacy in insulin production in vitro — 1 year
  Assessment of the percentage of mature insulin and c peptide production in insulin producing stem cells.
• Insulin producing mesenchymal stem cells efficacy in insulin production in vitro — 1 year
  Assestment of percentage of mature insulin production and c peptide in insulin producing stem cells in response to different concentrations of glucose.
• Insulin producing mesenchymal stem cells efficacy in insulin production in vivo — 1 year
  Participants glycemic control will be assesed before and after insulin producing stem cells injection.

Trial sites (1)

More Ain Shams University trials in Egypt

Other trials for the same condition