Intra-Abdominal Instillation Of Fresh Frozen Plasma Versus Corticosteroids In Prevention Of Recurrent Attacks Of Adhesive Intestinal Obstruction: A 2 Years' Experience Clinical Study

Condition(s) studied

Investigational drug(s) / intervention(s)

intra-abdominal instillation of corticosteroids: after adhesiolysis, peritoneal lavage with diluted corticosteroids will be instillated intra-abdominally

intra-abdominal instillation of fresh frozen plasma: after adhesiolysis, peritoneal lavage with diluted FFP will be instillated intra-abdominally

Study summary

Adhesive Intestinal obstruction is an inevitable complication of abdominal surgery with significant morbidity associated with poor quality of life and predispose to repeated hospitalization. Most of them (73% - 90%) can be managed conservatively.Despite advances in surgery, 15to 30% require surgical intervention primarily or due to failure of conservative management. Because of the nature of the disease recurrence has been estimated to be 30%.Many attempts to prevent formation of postoperative adhesions have been tried. In this trial, we will study the effect of corticosteroids and FFP in prevention of adhesive small bowel obstruction recurrence for follow up of 2 years duration.

Eligibility

Primary outcome measure(s)

• intestinal obstruction — from 1 day to 2 years post operative
  intestinal obstruction is detected if the patient had constipation and vomiting with ultrasound showing dilated bowel and to and fro movement and the plain erect shows multiple air fluid levels
• bowel injury — from 1 day to 2 years post operative
  bowel injury will be detected if intestinal contents present in the drain or wound
• wound infection — from 1 day to 2 weeks post-operative
  wound infection is detected if there is pus in the drain or wound

Trial sites (2)

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