Comparing Different Startegies of Positive Pressure Ventilation in Children

Condition(s) studied

Investigational drug(s) / intervention(s)

volume controlled ventilation: Pediatric patients in the VCV group (n= 30) received volume-controlled ventilation, target tidal volume was set at 7 mL/kg, with a respiratory rate of 16 breaths/min and a respiratory ratio of 1:2.

pressure controlled ventilation: Pediatric patients in the PCV group(n=30) received pressure-controlled ventilation. The initial parameters will be as follows: the peak inspiratory pressure (PIP) will set to provide a tidal volume of 7 ml/kg , respiratory rate will be 16 breaths/min, inspiratory to expiratory ratio was 1:2 with an upper limit of PIP of 20 cm H2O.

pressure controlled volume grantanteed ventilation: Pediatric patients in the PCV-VG group (n=30)will be conducted with pressure-controlled volume-guaranteed ventilation, target tidal volume will set at 7 mL/kg, with a respiratory rate of 16 breaths/min and a respiratory ratio of 1:2.

Study summary

The most basic modes of mechanical ventilation are volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV). VCV guarantees a target volume of ventilation using a constant flow, but may lead to high peak airway pressure (Ppeak) during the gas insufflation . In PCV mode, on the other hand,

Eligibility

Primary outcome measure(s)

• (PIP) — within one hour
  peak inspiratory pressure
• Pplat — within one hour
  plateau airway pressure
• (Cdyn) — within one hour
  pulmonary dynamic compliance
• (RAW — within one hour
  airway resistance
• VT — within one hour
  exhaled tidal volume
• EtCO2 — within one hour
  end-expiratory carbon dioxide
• Vd/VT — within one hour
  physiologic dead space over tidal volume

Trial sites (1)

More Beni-Suef University trials in Egypt