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Clinical Trials in Denmark / NCT07822217
Active, not recruiting Observational

Patients With a Single, Small (2 cm or Less) Cancer Nodule in the Thyroid Gland Will be Offered Active Surveillance Initially for 5 Years. In Case of Cancer Growth or Changes in Ultrasonographic Appearance, Further Treatment Will be Offered.

NCT07822217 · tracked via the Priya Life Science Denmark tracker
Sponsor
University of Aarhus
Phase
Observational
Started
2026-03-01
Last updated
2026-09-16

Condition(s) studied

Thyroid CancerActive Surveillance

Study summary

Patients with a single, small (less than 2 cm) cancer nodule in the thyroid gland will be offered active surveillance initially for 5 years. In case of cancer growth or changes in ultrasonographic appearance, further treatment will be offered.

Eligibility

Sex
ALL
Min age
30 Years
Max age
—
Healthy volunteers
No
Inclusion criteria: * age of 30 years or older AND * single, well-defined tumor in the thyroid gland, with a FNAB suspicious of cancer or diagnostic of cancer (category V or VI in the Bethesda system) AND * tumor size of 2 cm or less in all dimensions. Exclusion criteria: * suspicion of disseminated disease because of: * PET-positive lymph nodes on the neck * suspicious lymph-nodes by neck ultrasonography (US) * signs of capsular invasion of the tumor * suspicion of metastatic disease due to findings on PET-CT-scan or thoracic CT-scan; OR * tumor placement at a high-risk location (in the thyroid capsule or near the trachea) OR * previous thyroid surgery OR * concomitant hyperparathyroidism (ionized calcium \> 1.32 mmol/L and PTH \> 6 pmol/L) OR * if the patient is pregnant OR * If the patient is unable to give informed consent.

Primary outcome measure(s)

  • Treatment — 24 months
    The need for treatment due to tumor growth within 24 months (cumulative incidence)

Trial sites (1)

FacilityCityRegionStatus
Department of Otorhinolaryngology, Aarhus University Hospital Aarhus Denmark

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Other trials for the same condition

Radiofrequency Ablation Versus Hemithyroidectomy for Small Thyroid Cancers Recruiting
Active Surveillance for Bethesda IV Thyroid Nodules Recruiting
Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism Recruiting
Thyroid Nodule Gene Sequencing in a Danish Population Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07822217 on ClinicalTrials.gov ↗ ← All trials in Denmark