The Impact of Inflammation on Skeletal Muscle Maintenance in Hospitalized Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

Single leg training: All subjects will train one leg twice daily.

Study summary

The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .

Eligibility

Primary outcome measure(s)

• FSR in high vs. low inflammation group — 7 days (or until hospital discharge)
  The primary outcome is the muscle protein fractional synthesis rate (FSR) in the high inflammation group vs. the low inflammation group

Trial sites (1)

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