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Clinical Trials in Denmark / NCT05746650
Recruiting Not applicable

Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury

NCT05746650 · tracked via the Priya Life Science Denmark tracker
Sponsor
Bispebjerg Hospital
Phase
Not applicable
Started
2023-02-24
Last updated
2025-09-24

Condition(s) studied

Muscle Injury

Investigational drug(s) / intervention(s)

Electrical stimulationGrowth hormone (somatropin) →Control (No electrical stimulation, nor growth hormone)

Electrical stimulation: Experimentally induced muscly injury via. neuromuscular electrical stimulation of the hamstring muscles

Growth hormone (somatropin): Daily injection of growth hormone

Control (No electrical stimulation, nor growth hormone): No electrical stimulation, nor growth hormone

Study summary

The study is a 2-week human study where 40 patients who are scheduled to undergo reconstructive knee surgery are randomized to administration of GH or placebo following or without neuromuscular electrical stimulation of hamstring muscles.The overall aim is to determine, the role of muscle connective tissue protein synthesis in muscle injury and repair.

Eligibility

Sex
ALL
Min age
18 Years
Max age
35 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Healthy men and women scheduled to undergo reconstructive knee surgery * BMI 18-35 Exclusion Criteria: * Former or current use of growth hormone or anabolic steroids * Use of corticosteroids in the past 3 months * Use of any medication known to affect muscle or tendon turnover * Former participation in a study using deuterated water * Chronic diseases

Primary outcome measure(s)

  • Difference in muscle and myotendinous junction protein synthesis in regenerating vs. control muscle — 2 years
    Fractional synthesis rates based on D2O (deuterated water) intake and deuterium labelled alanine in tissue

Trial sites (1)

FacilityCityRegionStatus
Bispebjerg Hospital Copenhagen Denmark Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05746650 on ClinicalTrials.gov ↗ ← All trials in Denmark