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Recruiting Observational

Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?

NCT06896682 · tracked via the Priya Life Science Denmark tracker
Phase
Observational
Started
2025-07-08
Last updated
2026-03-13

Condition(s) studied

Postbariatric Hypoglycemia

Study summary

The goal of this observational study is to learn about how bariatric surgery affects the metabolism of cortisol.

The main question it aims to answer is whether changes in cortisol contribute to the development of reactive hypoglycemia?

100 individuals who have previously undergone bariatric surgery, are planned to be included.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: Participants must have undergone one of the following bariatric procedures at least 12 months prior: * Roux-en-Y gastric bypass * Gastric sleeve Exclusion Criteria * Pregnancy and breastfeeding * Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration * Use of corticosteroid medications, such as prednisolone * Use of opiod-containing medication * Use of medications containing estrogen, such as hormone therapy for menopause * Known adrenal disease affecting cortisol metabolism, including autonomous cortisol production and Cushing's syndrome * Diabetes that does not require medical treatment * Previously diagnosed reactive hypoglycemia after bariatric surgery requiring medical treatment

Primary outcome measure(s)

  • Changes in serum cortisol during mixed meal test — 0, 30, 60, 90, 120, 150, 180 minutes (visit 2)
    cortisol at nadir glucose during the mixed meal test - cortisol at the start of the meal test

Trial sites (1)

FacilityCityRegionStatus
Esbjerg Hospital Esbjerg Denmark Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06896682 on ClinicalTrials.gov ↗ ← All trials in Denmark