Oral Versus Intravenous Fluid Therapy in the Emergency Department

Condition(s) studied

Investigational drug(s) / intervention(s)

Oral fluids: Any fluid volume prescribed by the physician during the ED stay is administered orally.

Intravenous fluids: Any fluid volume prescribed by the physician during the ED stay is administered intravenously.

Study summary

The goal of this randomized clinical feasibility trial is to determine whether oral fluid therapy can achieve prescribed fluid volumes as effectively as intravenous fluid therapy in adult patients admitted to the emergency department who require fluid treatment.

The main questions it aims to answer are:

Are patients receiving oral fluids equally likely to achieve the prescribed fluid volume compared with patients receiving intravenous fluids?

Is it feasible to conduct a randomized trial of oral versus intravenous fluid therapy in the emergency department, based on recruitment rate and protocol adherence?

Researchers will compare oral tap water administration with standard intravenous crystalloid therapy to assess whether oral fluids are non-inferior in achieving prescribed fluid volumes and to evaluate feasibility outcomes.

Participants will:

Be randomized to receive either oral tap water or intravenous crystalloid fluids during their stay in the emergency department

Receive a fluid volume and administration rate determined by the treating physician

Be monitored according to standard clinical practice during the emergency department stay

Have fluid intake, vital signs, and clinical outcomes recorded, with follow-up through routine health records up to 30 days after inclusion

Eligibility

Primary outcome measure(s)

• Percentage of patients achieving the fluid volume prescribed during the first 48 hours in the emergency department — From inclusion until end of participation. End of participation is defined as the timepoint of leaving the emergency department or after 48 hours, whichever happens first.

Trial sites (3)

More Esbjerg Hospital - University Hospital of Southern Denmark trials in Denmark