The Effect of Short-term Bed Rest on Cardiac Function Measured by Cardiac Magnetic Resonance Imaging

Condition(s) studied

Investigational drug(s) / intervention(s)

Bedrest: Investigation of the effect of short-term bed rest (3 hours) on heart function, measured by cardiac magnetic resonance, in healthy participants ( males and females)

Study summary

The primary objective of this study is to investigate the effect of short-term bed rest (4 hours) on heart function, measured by cardiac magnetic resonance (CMR), in healthy participants. This aim will be addressed through a single-arm repeated study, assessing participants during three hours of bedrest.

The hypothesis is that short-term bed rest will decrease cardiac output measured by repeated CMR scans.

This study will also investigate the reproducibility of CMR within a narrow time frame. Limited data are available on these aspects, despite their critical importance for conducting consecutive examinations, both in clinical practice and research trials10-12. The study also aims to investigate the appliances of short-time measures of cardiac function.

Eligibility

Primary outcome measure(s)

• cardiac output — 0-4 hours
  Change in cardiac output will be measured assessed by repeated cardiac magnetic resonance measurement after shortterm bed rest compared with before bedrest.

Trial sites (1)

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