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Clinical Trials in Denmark / NCT07692646
Recruiting Not applicable

The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix

NCT07692646 · tracked via the Priya Life Science Denmark tracker
Sponsor
University of Copenhagen
Phase
Not applicable
Started
2026-06
Last updated
2026-07-09

Condition(s) studied

FastingObesity (BMI>30)Sex Difference

Investigational drug(s) / intervention(s)

Diet

Diet: Long-term fasting (84 hours), physiological testing before and after fasting: sampling of blood, abdominal adipose tissue and skeletal muscle for molecular analysis and respiratory measurements at rest.

Study summary

The interventional study will recruit four groups (n=10 per group): Young men and women with normal weight (BMI 18-25), and young men and women with obesity (BMI \>30). The study will investigate the effect of 84 hours of fasting on peak fat oxidation, mitochondrial coupling and the extracellular matrix.

Eligibility

Sex
ALL
Min age
18 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Healthy normal weight men aged \[18,40\] and BMI \[18,25\] * Healthy normal weight women \[18,40\] and BMI \[18,25\] * Healthy obese men \[18,40\] and BMI \[30,40\] * Healthy obese women \[18,40\] and BMI \[30,40\] Exclusion Criteria: * Present or former cardiovascular disease and chronical inflammatory disease * Consumption of medications and supplements that influence substrate use at rest and/or during exercise * Pregnancy

Primary outcome measure(s)

  • The effect of fasting and obesity on protein glycosylation of the extracellular matrix in adipose tissue — The fasting will last approximately 84 hours.
    The composition and protein glycosylation of the extracellular matrix will be measured in abdominal subcutaneous adipose tissue samples in 20 healthy normal weight men and women and 20 healthy obese men and women.

Trial sites (1)

FacilityCityRegionStatus
Department of Biomedical Sciences Copenhagen Denmark Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07692646 on ClinicalTrials.gov ↗ ← All trials in Denmark