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Clinical Trials in Denmark / NCT06335420
Recruiting Not applicable

Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps

NCT06335420 · tracked via the Priya Life Science Denmark tracker
Sponsor
Odense University Hospital
Phase
Not applicable
Started
2024-06-20
Last updated
2025-11-20

Condition(s) studied

Colorectal Cancer Prevention

Investigational drug(s) / intervention(s)

Carrot juice from Yellowstone carrots cultivarsPlacebo juice

Carrot juice from Yellowstone carrots cultivars: Consumption of 100 ml of carrot juice daily for 1 year

Placebo juice: Consumption of 100 ml of placebo juice daily for 1 year

Study summary

The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel.

The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans?

Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar.

Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers. 2. Acceptance of the treatment and follow-up program. 3. Capability to understand and follow the instructions. Exclusion Criteria: 1. Patients allocated to "high-risk" group because of many small polyps (\>4). 2. Pregnancy. 3. Known relevant allergies. 4. Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids). 5. Patients with different neoplastic disease under treatment (Chemo-/Radio-/Imunotherapy). 6. Severe comorbidity NYHA III-IV. 7. Lynch syndrome.

Primary outcome measure(s)

  • Number and size of recurrent polyps found at the one-year follow up colonoscopy — 1 year
    The combined endpoint (number x size of recurrent polyps) after 1 year of treatment.

Trial sites (1)

FacilityCityRegionStatus
Department of Surgery, Odense University Hospital Odense Denmark Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06335420 on ClinicalTrials.gov ↗ ← All trials in Denmark