Klinefelter Syndrome and Testosterone Treatment in Puberty

Condition(s) studied

Investigational drug(s) / intervention(s)

Testosterone gel: Two years treatment with testosterone

Placebo: Two years treatment with placebo

Study summary

The goal of this randomized clinical trial is to study the effect of testosterone replacement therapy during puberty in boys with Klinefelter syndrome (KS, 47,XXY).

The main questions to answer are how treatment with testosterone will affect body fat mass, lipid and glucose metabolism, growth and body proportions, bone mineralization as well as effects on neurocognitive development and emotional and social difficulties.

Participants will be randomized to two years treatment with testosterone or placebo.

Eligibility

Primary outcome measure(s)

• Changes in body fat mass — Baseline and 1 and two years
  Evaluation of body fat percentage by whole body dual energy x-ray absorptiometry (DEXA) scan

Trial sites (1)

Other trials for the same condition