Oral Health and Adverse Pregnancy Complications

Condition(s) studied

Investigational drug(s) / intervention(s)

Periodontal treatment: Periodontal treatment

Study summary

Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected. Periodontitis is accompanied by a low-grade systemic inflammation and can be harmful to the general health of the woman, contribute to pre-term birth and adversely influence the future health and metabolism of the offspring. Despite this, studies indicate that 40% of Danish women in childbearing age do not visit a dentist regularly. The PROBE controlled intervention study will investigate the beneficial effect of treatment of periodontal disease during pregnancy on fetal growth, preterm delivery and birth weight.

Eligibility

Primary outcome measure(s)

• Prevalence of preterm birth — 18 months
  Defined as any birth before 37 completed weeks of gestation
• Prevalence of low birthweight — 18 months
  Defined as a birth weight of less than 2500 gram
• Increased risk markers for preeclampsia — 18 months
  Defined as hypertension and proteinuria
• Prevalence of gestational diabetes — 18 months
  Defined as glucose intolerance

Trial sites (3)

More University Hospital Bispebjerg and Frederiksberg trials in Denmark

Other trials for the same condition