Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome

Condition(s) studied

Investigational drug(s) / intervention(s)

No intervention other than obtaining biopsies: Skin, fat, and muscle biopsies will be obtained

Indocyanine green (ICG): Indocyanine green will be injected to evaluate the lymphatic system.

Study summary

100 women with karyotype verified TS, previously examined at 4 study visits during a 19-year period will be asked to participate in a 5th study visit. Healthy age-matched females will be included as controls in a ratio 2:1.

The aim is to examine and quantify the cardiovascular and lymphatic system in women with TS. The investigators will study a possible causal mechanism between the known pathologic phenotype and alterations in these systems to understand, prevent or treat the life-threatening complications in TS.

Eligibility

Primary outcome measure(s)

• Grade dysfunction of clinical and subclinical lymphedema using Indocyanine Green Lymphography and Magnetic Resonance Lymphangiography. — 3 year
  Lymphedema will be graded in a total score according to the International Society of Lymphology. The stages are: Stage 0: Subclinical lymphedema. • Stage 1: Early, reversible pitting edema. Stage 2: Irreversible lymphedema. Stage 3: End-stage lymphedema.
• Detecting low-grade inflammation in Turner Syndrome preforming FDG-PET/CT-scans to locate low grade inflammation. — 3 years
• Heat maps of the distribution of wall shear stress in the aorta — 3 years
  Using 4D-flow analyses heat maps of the aorta will be made to illustrate the distribution of wall shear stress.

Trial sites (1)

More University of Aarhus trials in Denmark

Other trials for the same condition