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Clinical Trials in Denmark / NCT06083948
Recruiting Phase 2/3

Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia

NCT06083948 · tracked via the Priya Life Science Denmark tracker
Sponsor
University of Aarhus
Phase
Phase 2/3
Started
2023-12-20
Last updated
2026-03-19

Condition(s) studied

Hypotension

Investigational drug(s) / intervention(s)

Noradrenalin →Phenylephrine →

Noradrenalin: Infusion of noradrenaline during anesthesia and surgery

Phenylephrine: Infusion of phenylephrine during anesthesia and surgery

Study summary

The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion on blood flow and oxygen delivery to the brain and various other organs in anesthetized neurosurgical patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: 1. Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI). 2. Scheduled for elective supratentorial craniotomy. 3. Patients aged between 18 and 75 years. 4. American Society of Anesthesiologists status 1-3 Exclusion Criteria: 1. History of allergy or intolerance to one of the study medications. 2. Active treatment with monoamine oxidase inhibitors. 3. An American Society of Anesthesiologists (ASA)physical status IV-VI. 4. Pregnancy or breastfeeding. 5. Inability to provide written informed consent -

Primary outcome measure(s)

  • Cerebral blood flow — Up to 3 hours (measured on the day of surgery prior to the surgical procedure)
    Blood flow measured in milliliters per minute through selected regions of the brain as determined by Positron Emission Tomography

Trial sites (1)

FacilityCityRegionStatus
Aarhus University Hospital Aarhus Denmark Recruiting

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Other trials for the same condition

Early Initiated Vasopressor Therapy in the Emergency Department Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06083948 on ClinicalTrials.gov ↗ ← All trials in Denmark