SGLT2 Inhibitor TrEatment iN Patients Awaiting cOronary arTery bYpass Surgery to Reduce Post-opErative AF
Condition(s) studied
Investigational drug(s) / intervention(s)
Dapagliflozin 10mg Tab: Dapagliflozin once daily for a minimum of seven days while awaiting scheduled CABG and up until discharge with a short interruption for surgery.
Placebo Tab: Matching placebo once daily for a minimum of seven days while awaiting scheduled CABG and up until discharge with a short interruption for surgery.
Study summary
The goal of this randomized, double-blinded, controlled clinical trial is to investigate if treatment with an sodium-glucose cotransporter-2 inhibitor (SGLT2) during the unique time window before coronary artery bypass surgery (CABG), can reduce the incidence of post-operative atrial fibrillation and/or acute kidney injury in patients with chronic coronary syndrome. The main questions it aims to answer are:
* Does treatment with an SGLT2 inhibitor during the waiting time and stable post-operative period, in patients with chronic coronary syndrome scheduled for CABG, reduce the risk of new onset atrial fibrillation compared to placebo?
* Does treatment with an SGLT2 inhibitor during the waiting time and stable post-operative period, in patients with chronic coronary syndrome scheduled for CABG, reduce the risk of acute kidney injury before hospital discharge compared to placebo?
Participants will be administered dapagliflozin 10 mg once daily or placebo for a minimum of seven days while awaiting scheduled CABG and up until discharge, with a short interruption for surgery. The active arm will be compared to the placebo arm to see if dapagliflozin can reduce the incidence of post-operative atrial fibrillation and/or acute kidney injury.
Eligibility
Primary outcome measure(s)
- Incidence of new onset post-operative atrial fibrillation of at least 30 seconds — From CABG to discharge post-operatively up to four weeks
ECG or telemetry
Trial sites (8)
| Facility | City | Region | Status |
|---|---|---|---|
| St. Anne University Hospital | Brno | Czechia | Not Yet Recruiting |
| Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark | Aarhus | Denmark | Recruiting |
| Department of Cardiothoracic Surgery, Kobenhavn | Copenhagen | Denmark | Not Yet Recruiting |
| Odense University Hospital | Odense | Denmark | Not Yet Recruiting |
| Sahlgrenska University Hospital | Gothenburg | Sweden | Recruiting |
| Linköping University Hospital | Linköping | Sweden | Not Yet Recruiting |
| Skane University Hospital | Lund | Sweden | Recruiting |
| Department of cardiology | Örebro | Sweden | Recruiting |
More Region Örebro County trials in Denmark
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05852704 on ClinicalTrials.gov ↗ ← All trials in Denmark