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Clinical Trials in Denmark / NCT05123313
Active, not recruiting Not applicable

Medication Use and Quality of Life Among Older People

NCT05123313 · tracked via the Priya Life Science Denmark tracker
Sponsor
Odense University Hospital
Phase
Not applicable
Started
2021-10-26
Last updated
2025-08-08

Condition(s) studied

Quality of LifeReduction, Harm

Investigational drug(s) / intervention(s)

Deprescribing intervention

Deprescribing intervention: The intervention is comprised of a minimum of three consultations with a general practitioner (GP), where adjustment of the patient's medication is made according to the patient's preference, goals and needs Consultation 1: Patient and GP discuss how the patient feels about their medical treatment, and the GP provides the patient with written material for the patient to prepare prior to the next consultation. Consultation 2: A clinical pharmacist have beforehand examined the patient's medication list and provided suggestions to the GP on which drugs can be deprescribed. The patient and GP discuss the patient's preferences and initiate deprescribing initiatives aligned with the patient's priorities. Consultation 3: Patient and GP follow up on the changes initiated and initiate new deprescribing initiatives if such can be identified. If needed, subsequent consultations (Consultation X) are planned until the patient and GP consider the patient's medical treatment optimal.

Study summary

This project will provide new evidence on how to optimize medication use among older people with limited life expectancy. This will be done by testing whether a patient-centered deprescribing intervention, focused on aligning medical treatment with patients' preferences, can improve quality of life among older people with limited life expectancy.

Eligibility

Sex
ALL
Min age
80 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Aged ≥ 80 years * Take ≥ 8 different medications * Have a life expectancy of \<2 years, estimated via the Surprise Question ("Would you be surprised if this patient died within 1-2 years?") by the general practitioner * have a Mini-Mental State Exam (MMSE) score of ≥18 * Are able to provide informed consent Exclusion Criteria: * Not able to communicate * Does not speak and understand Danish

Primary outcome measure(s)

  • HEALTH-RELATED QUALITY OF LIFE — Baseline
    Health-related quality of life will be measured using the Danish version of the Short Form 12 Health Survey Version 2 (SF-12v2).
  • CHANGE FROM BASLINE HEALTH-RELATED QUALITY OF LIFE AT 3 MONTHS — 3 months
    Health-related quality of life will be measured using the Danish version of the Short Form 12 Health Survey Version 2 (SF-12v2).
  • CHANGE FROM BASLINE HEALTH-RELATED QUALITY OF LIFE AT 6 MONTHS — 6 months
    Health-related quality of life will be measured using the Danish version of the Short Form 12 Health Survey Version 2 (SF-12v2).
  • HEALTH-RELATED QUALITY OF LIFE (DEPRESSION) — Baseline
    Health-related quality of life will be measured using the Danish version of the Depression List (DL).
  • CHANGE FROM BASLINE HEALTH-RELATED QUALITY OF LIFE (DEPRESSION) AT 3 MONTHS — 3 months
    Health-related quality of life will be measured using the Danish version of the Depression List (DL).
  • CHANGE FROM BASLINE HEALTH-RELATED QUALITY OF LIFE (DEPRESSION) AT 6 MONTHS — 6 months
    Health-related quality of life will be measured using the Danish version of the Depression List (DL).
  • MORTALITY — 3 months
    Mortality will be assessed through the nationwide Danish Central Person Registry (CPR).
  • MORTALITY — 6 months
    Mortality will be assessed through the nationwide Danish Central Person Registry (CPR).
  • MORTALITY — 12 months
    Mortality will be assessed through the nationwide Danish Central Person Registry (CPR).

Trial sites (1)

FacilityCityRegionStatus
Odense University Hospital Odense Region Syddanmark

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05123313 on ClinicalTrials.gov ↗ ← All trials in Denmark