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Clinical Trials in Denmark / NCT04996550
Starting soon Observational

Are Carvedilol and Metoprolol Succinate Comparable Treatments in Heart Failure Patients With Reduced Ejection Fraction

NCT04996550 · tracked via the Priya Life Science Denmark tracker
Sponsor
Odense University Hospital
Phase
Observational
Started
2022-01-03
Last updated
2021-08-16

Condition(s) studied

Chronic Heart Failure

Investigational drug(s) / intervention(s)

Carvedilol →Metoprolol Succinate →

Carvedilol: To compare the efficacy of carvedilol and metoprolol succinate on all-cause mortality or first hospitalization for worsening heart failure in patients with heart failure with reduced ejection fraction with an indication for treatment with beta-blockers.

Metoprolol Succinate: To compare the efficacy of carvedilol and metoprolol succinate on all-cause mortality or first hospitalization for worsening heart failure in patients with heart failure with reduced ejection fraction with an indication for treatment with beta-blockers.

Study summary

The objective of CROWD-COMPARE is to compare the efficacy of carvedilol and metoprolol succinate on all-cause mortality or first hospitalization for worsening heart failure in patients with heart failure with reduced ejection fraction with an indication for treatment with beta-blockers.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥18 years * NYHA ≥ II * LVEF ≤40% Exclusion Criteria: * No indication for beta-blocker treatment or contraindications for the two for the two study drugs (Carvedilol or metoprolol succinate)

Primary outcome measure(s)

  • A combined endpoint of all-cause mortality or first hospitalization for worsening heart failure. — Four years with randomized cluster allocation and two year of follow-up.
    To compare the efficacy of carvedilol and metoprolol succinate in patients with heart failure with reduced ejection fraction with an indication for treatment with beta-blockers.

Trial sites (1)

FacilityCityRegionStatus
Department of Cardiology, Odense University Hospital Odense Region Syddanmark

On this site

📄 Coreg (carvedilol) drug profile →

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Other trials for the same condition

Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure Recruiting
Biomarkers as Predictors of Chronic Heart Failure in Patients With Type 2 Diabetes Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04996550 on ClinicalTrials.gov ↗ ← All trials in Denmark