Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study
Condition(s) studied
Study summary
Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system, some which can become metastatic. It is a very rare disease and the tumours are often detected late. Approximately 50 % of the tumours are caused by germline genetic variants screening programmes are recommended for patients and their family members; however, they are not yet well-targeted with respect to individual prognosis. In this study the investigatorscaim to characterize the genotype-phenotype associations in all Danish patients (n=400) diagnosed with PPGLs who have been followed in tertiary centres using medical records and national registries. To this end novel immunohistochemical, genetic, and epigenetic biomarkers in tumour tissues samples from biobank material (blood samples and tumour tissue) will be investigated to develop a comprehensive predictive algorithm for disease prognosis. The study will provide a clinical tool for an improved targeted screening program and subsequently prevention of disease development.
Eligibility
Primary outcome measure(s)
- Malignant or non-malignant disease — 25 ys (1996-2021) retrospective data collection of approximately 400 patients until death or until today.
Defined as metastatic disease
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| Rigshospitalet | Copenhagen | Denmark | |
| National University Hospital, Department of Medical Endocrinology | Copenhagen | Denmark |
More Copenhagen University Hospital, Rigshospitalet trials in Denmark
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04788927 on ClinicalTrials.gov ↗ ← All trials in Denmark