Ischemic Postconditioning in STEMI Patients Treated With Primary PCI

Condition(s) studied

Investigational drug(s) / intervention(s)

Ischemic postconditioning: After 60 seconds of reperfusion, ischemic postconditioning with an adequately sized balloon (60 reperfusion/60 seconds re-occlusion, four cycles) will be performed

Conventional: State of the art primary PCI, however thrombectomy is not allowed

Study summary

In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI patients who present with TIMI0-1 undergoing primary PCI

Eligibility

Primary outcome measure(s)

• All cause mortality or hospitalization for heart failure — From date of randomization until the date of first documented hospitalization for heart failure or date of death from any cause, whichever came first, assessed up to 280 events have been adjudicated or up to 36 months
  Composite endpoint of all cause mortality or hospitalization for heart failure which ever occur first

Trial sites (1)

More Copenhagen University Hospital, Rigshospitalet trials in Denmark