Ireland
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Recruiting Observational

68Ga-labeled Cholecystokinin Receptor (CCK2R) Targeted Molecular Probes in Early Tumor Diagnosis

NCT07914764 · tracked via the Priya Life Science China tracker
Phase
Observational
Started
2026-08-01
Last updated
2026-11-04

Condition(s) studied

Medullary Thyroid CarcinomaSmall Cell Lung Cancer ( SCLC )Gastric Adenocarcinoma

Investigational drug(s) / intervention(s)

Intravenous injection of 68Ga-YQ-CC05 for PET-CT examination

Intravenous injection of 68Ga-YQ-CC05 for PET-CT examination: Intravenous injection of 68Ga-YQ-CC05 imaging agent, with a dose of 0.05 mCi/Kg body weight, followed by PET-CT imaging 60 minutes after administration

Study summary

Evaluate the safety of the novel radioactive nuclide-labeled cholecystokinin receptor (CCK2R) targeted molecular probe, 68Ga-YQ-CC05, in clinical application, and verify its effectiveness in tumor diagnosis.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Volunteer to participate in the trial, with the patient or their legal guardian signing the informed consent form; * Volunteers are not limited by gender, and the age range is from 18 to 75 years old, inclusive; * Other imaging examination methods (CT, MRI, etc.) reveal tumor occupying lesions; * Tumor patients who can obtain the final pathological results. * Kidney: GFR \> 50 ml/min, ERPF \> 280 ml/min, platelet count (PLT) \> 75,000/μL, white blood cell (WBC) \> 3,000/μL, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than 3 times the normal value. Exclusion Criteria: * Individuals with a history of allergy to similar drugs (drugs with similar chemical or biological components to CCK2R), allergic constitution, or current allergic diseases; * Those who are currently participating in other clinical drug studies, or have previously participated in any clinical drug studies (excluding vitamins and minerals); * Other uncontrollable clinical issues (such as HIV, hepatitis C virus infection, active hepatitis B, or other severe chronic infections, as well as severe mental, neurological, cardiovascular, respiratory, and other systemic diseases); * Red blood cells (RBC) count less than 4×10\^12, white blood cells (WBC) count less than 3×10\^9, hemoglobin level less than 110g/L, and platelet count (PLT) less than 75,000×10\^9; * Obvious abnormalities in liver and kidney function, with GFR less than 50 ml/min; * Tumor burden greater than 50%, or significant spinal cord compression; * Expected survival duration less than half a year; chemotherapy within 6 months; * Having severe acute concomitant diseases or severe treatment-resistant mental disorders; * Pregnant and lactating women (where pregnancy is defined as a positive urine pregnancy test result); * Patients who are physically unfit for radiological examinations; * Other situations where the researcher deems it inappropriate for the participant to participate in the trial.

Primary outcome measure(s)

  • SUVmax of lesion uptake value — 60 minutes after administration

Trial sites (1)

FacilityCityRegionStatus
Nanjing First Hospital Nanjing Jiangsu Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07914764 on ClinicalTrials.gov ↗ ← All trials in China