3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features
Condition(s) studied
Study summary
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with vestibular schwannoma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for risk stratification and prediction of tumor behavior, and to evaluate the relationship between MRE characterization of tumor mechanical features and patients' clinical prognosis.
Eligibility
Primary outcome measure(s)
- Agreement Between MRE Stiffness and Intraoperative Tumor Consistency — Intraoperative (Day of Surgery)
The primary outcome is the correlation between preoperative 3D MRE-derived shear stiffness values and intraoperative tumor consistency as assessed by the neurosurgeon using a standardized ordinal scale (1-5). Agreement will be evaluated using Spearman correlation and Bland-Altman analysis.
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Shengjing hospital | Shenyang | Liaoning | Recruiting |
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Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07844460 on ClinicalTrials.gov ↗ ← All trials in China