Clinical Trials in China / NCT07835984
Starting soon
Phase 2
A Study to Evaluate Efficacy and Safety of GW906 Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by One or Two Antihypertensive Medications
NCT07835984 · tracked via the Priya Life Science China tracker
Condition(s) studied
Hypertension
Investigational drug(s) / intervention(s)
GW906 →Placebo
GW906: Subcutaneous injection. 24 weeks
Placebo: Subcutaneous injection. 24 weeks
Study summary
The purpose of this study is to evaluate the effect of GW906 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of GW906 as add-on therapy.
Eligibility
Inclusion Criteria:
* Age ≥ 18 years, of either sex.
* Treated hypertension on stable therapy with up to 1 or 2 antihypertensive medications. Stable therapy is defined as having no change in antihypertensive medication or dose within 4 weeks prior to randomization.
* Mean sitting systolic blood pressure (msSBP) ≥ 140 mmHg and \< 180 mmHg at the randomization visit.
* Willing to participate in the study and provide written informed consent.
Exclusion Criteria:
* Secondary hypertension.
* orthostatic hypotension.
* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5× upper limit of normal (ULN); Total bilirubin \> 1.5 × ULN; International normalized ratio (INR) \> 2.0; Serum potassium \> 5.0 mmol/L or \< 3.5 mmol/L; eGFR≤30 mL/min/1.73m\^2.
* Received an investigational agent within the last 3 months.
* Type 1 diabetes mellitus, poorly controlled Type 2 diabetes mellitus.
* History of any cardiovascular event within 12 months.
* History of intolerance to SC injection(s).
Primary outcome measure(s)
- Change from baseline in mean sitting systolic blood pressure (msSBP) at Week 12 — Baseline and Month 3
msSBP will be measured in the office using a validated sphygmomanometer, with the participant seated and resting quietly for at least 5 minutes. The primary endpoint is the change from baseline, calculated as the Week 12 value minus the baseline value, expressed in mmHg
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| The Second Affiliated Hospital Zhejiang University School of Medicine | Hangzhou | Zhejiang |
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07835984 on ClinicalTrials.gov ↗ ← All trials in China