High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease

Condition(s) studied

Investigational drug(s) / intervention(s)

High-flow nasal cannula: Using high-flow nasal cannula oxygenation

Study summary

Hypoxemia is the most common adverse event during propofol sedation for gastrointestinal endoscopy in patients with chronic obstructive pulmonary disease (COPD) due to diminished pulmonary reserve. Although high-flow nasal cannula (HFNC) oxygenation has been shown to effectively reduce hypoxemia during sedated endoscopy in obese patients, its application in COPD patients remains an evidence gap, largely owing to the traditional concern that high-concentration oxygen may suppress respiratory drive and exacerbate CO₂ retention. This study aims to investigate whether HFNC can reduce the incidence of hypoxemia during sedated gastrointestinal endoscopy in patients with COPD.

Eligibility

Primary outcome measure(s)

• The incidence of hypoxemia — Patients will be followed for the duration of hospital stay, an expected average about 2 hours
  75% ≤ SpO2 \< 90% for \<60 s

Trial sites (1)

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