Sedated gastroscopy: All enrolled patients underwent sedated gastroscopy.
Study summary
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province. This aims to characterize the endoscopic features of esophageal diseases specific to the high-altitude population in Zaduo County.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Aged ≥18 years;
* Resided in Zaduo County for ≥6 months;
* Undergoing painless (sedated) gastroscopy at our institution;
* Absence of severe cardiopulmonary diseases or other conditions contraindicating gastroscopy;
* Voluntary provision of written informed consent.
Exclusion Criteria:
* Emergency endoscopy;
* History of partial or total esophagogastrectomy;
* Planned endoscopic ultrasound (EUS) or endoscopic submucosal dissection (ESD);
* Comorbidities including severe cardiac, hepatic, or renal dysfunction, or malignant tumors;
* Pregnancy or lactation, chronic alcoholism, or psychiatric disorders precluding cooperation;
* Participation in other interventional clinical trials within the recent past;
* Age \<18 years;
* Incomplete endoscopic examination (e.g., poor preparation, technical failure);
* Any other condition deemed unsuitable for participation by the investigator.
Primary outcome measure(s)
Proportion of reflux esophagitis — Within 1 week after gastroscopy The severity of reflux esophagitis (RE) was evaluated according to the Los Angeles (LA) classification\[1\]. Mucosal breaks were defined as visible discontinuities of the esophageal squamous epithelium. The grading criteria were as follows:
LA Grade A: One or more mucosal breaks, each no longer than 5 mm, confined to the mucosal folds.
LA Grade B: One or more mucosal breaks longer than 5 mm, but not continuous between the tops of two mucosal folds.
LA Grade C: Mucosal breaks continuous between the tops of two or more mucosal folds, involving less than 75% of the esophageal circumference.
LA Grade D: Mucosal breaks involving at least 75% of the esophageal circumference. The proportion of reflux esophagitis was defined as the number of patients diagnosed with reflux esophagitis divided by the total number of enrolled participants.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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