Study in Human iPSCs-derived RPE Cells Transplantation for Advanced (Late-stage) AMD

Inclusion Criteria: * (1)Age ≥50 years and ≤85 years, regardless of gender. * (2)Patients with atrophic AMD in the macular area (geographic atrophy \>250μm, involving the foveal center); or inactive neovascular AMD patients who have undergone treatment for wet AMD or have naturally converted to non-exudative AMD (referring to patients with fibrovascular scar formation, who are unresponsive to anti-VEGF treatment, and have no macular edema on OCT and/or no fluorescein leakage on FFA), with a scar diameter not exceeding 6 PD. * (3)Best-corrected visual acuity (BCVA) of the study eye ≥5 letters and ≤34 letters (using the ETDRS visual acuity chart). * (4)If both eyes meet the criteria, the more severely affected eye will be selected; if the severity is the same in both eyes, the right eye will be designated as the study eye. * (5)The patient or their legal representative has signed a written informed consent form. Exclusion Criteria: * Ocular Diseases: * (1)Vitreous hemorrhage in the study eye within 2 months prior to screening. * (2)Presence of a scar or fibrosis involving the fovea in the study eye, or a peripheral scar area greater than 6 PD, indicating severe irreversible visual loss. * (3)Presence of pseudoexfoliation syndrome, central retinal vein occlusion, intraocular hemorrhage causing visual loss, rhegmatogenous retinal detachment, macular hole, or active choroidal neovascularization in the study eye. * (4)Afferent pupillary defect (APD) in the study eye. * (5)Significant media opacity in the study eye (excluding lens opacities) that may interfere with visual function assessment or fundus examination. * (6)Acute infectious inflammation in either eye during the screening period. * (7)Patients with intraocular pressure higher than 25 mmHg despite medical treatment. * (8)Monocular blind patients. Ocular Treatments: * (9)The study eye has undergone focal/grid laser photocoagulation within 3 months prior to screening. * (10)The study eye has undergone any intraocular surgery within 3 months prior to screening. * (11) Any eye has received anti-angiogenic therapy (including any anti-VEGF agents, e.g., Aflibercept \[Eylea®\], Ranibizumab \[Lucentis®\], Bevacizumab \[Avastin®\]) within 1 month prior to screening; or has undergone cataract surgery within 1 month prior to screening with unstable postoperative ocular conditions. Systemic Diseases, Treatments, and Other Conditions: * (12)Patients with an allergic reaction or history of allergy to sodium fluorescein and indocyanine green, a history of allergy to protein products used for treatment or diagnosis, and patients with allergies to two or more drugs and/or non-drug factors, or those currently suffering from allergic diseases. * (13)Patients with uncontrolled diabetes (fasting blood glucose ≥7.0 mmol/L or 2-hour postprandial blood glucose ≥11.1 mmol/L). * (14)Patients with a history of surgical procedures within 1 month prior to screening, or those with unhealed wounds, ulcers, fractures, etc. * (15)Patients with uncontrolled hypertension (defined as a single measurement of systolic blood pressure \>180 mmHg, two consecutive measurements of systolic blood pressure \>160 mmHg, or diastolic blood pressure \>100 mmHg despite optimal treatment). * (16)Patients with a history of myocardial infarction within 6 months prior to enrollment. * (17)Patients with active disseminated intravascular coagulation or a significant tendency to bleed; patients who have used anticoagulant or antiplatelet aggregation drugs within 14 days prior to screening, except for aspirin/nonsteroidal anti-inflammatory drugs. * (18) Presence of any uncontrolled systemic clinical conditions, such as interstitial pneumonia, severe psychiatric, neurological, cardiovascular, or respiratory diseases, malignant tumors, Parkinson's disease, Alzheimer's disease, or other severe systemic disorders. * (19)Women of childbearing age with a positive pregnancy test during the screening period. Women who wish to breastfeed during the study period, and all patients of childbearing age (male and female) who do not agree to take effective contraceptive measures (such as intrauterine devices, oral contraceptives, or condoms) throughout the study period and for 30 days after the end of the visit period. * (20)Patients who have participated in or are currently participating in other clinical studies within 30 days prior to screening. * (21)Hemoglobin \<100 g/L, platelets ≤100×10\^9/L, neutrophil count \<1.0×10\^9/L, ALT/AST \>1.5×upper limit of normal (ULN), creatinine \>1.3 mg/dL. * (22)Subjects with any clinically significant finding in virological tests (HIV, HBV, HCV and TPPA). * (23)Patients deemed unsuitable for inclusion by the investigator, or other medical conditions that limit the subject's compliance, safety, or affect the results of the trial results.