Recurrence After Gastric and Intestinal Polyp Resection

NCT07314554 · tracked via the Priya Life Science China tracker

Sponsor

LanZhou University

Phase

Observational

Started

2026-07-26

Last updated

2026-06-09

Condition(s) studied

Gastric PolypsIntestinal PolypsColon PolypsColorectal PolypsAdenomatous PolypsGastric Adenoma and Early Gastric CancerColorectal Adenoma

Study summary

This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.

BACKGROUND: Gastric and intestinal polyps are common digestive diseases with potential for malignant transformation. Although endoscopic resection is the standard treatment, recurrence rates range from 10-50%, and the mechanisms and risk factors remain unclear.

OBJECTIVES:

Primary: To assess short-term (1-year) and long-term (3-year) recurrence rates after endoscopic polyp resection Secondary: To identify independent risk factors and develop a recurrence risk prediction model

DESIGN: Mixed retrospective-prospective cohort study

* Retrospective cohort: Patients who underwent polyp resection from 2021-2022, with follow-up data through 2024
* Prospective cohort: Patients enrolled from 2024-2025, with standardized follow-up through 2028

SETTING: Single tertiary referral center with \>10,000 endoscopic polyp resections performed since 2021

PARTICIPANTS: Approximately 1,600-1,800 adult patients (≥18 years) who underwent complete endoscopic resection of gastric or intestinal polyps

FOLLOW-UP:

* Short-term: 1 year post-resection (±2 months)
* Long-term: 3 years post-resection (±3 months)

MAIN OUTCOME: Recurrence rate defined as new polyp detection at original or different sites during endoscopic surveillance

POTENTIAL RISK FACTORS: Patient demographics, polyp characteristics (size, number, location, pathology), resection method, Helicobacter pylori status, lifestyle factors, and medication use

EXPECTED IMPACT: Results will inform personalized surveillance strategies and optimize resource allocation for post-polypectomy follow-up.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age 18 years or older * First-time endoscopic examination (gastroscopy or colonoscopy) at the study center * Pathologically confirmed polyp of any type (adenomatous, hyperplastic, inflammatory, fundic gland polyp, hamartomatous, serrated lesion) * Complete endoscopic resection performed (including EMR, ESD, snare polypectomy, hot biopsy forceps, or argon plasma coagulation) * Negative resection margins or complete resection assessed by pathology * At least one follow-up endoscopic examination completed (for retrospective cohort) or willingness to complete follow-up (for prospective cohort) * Complete baseline clinical data available Exclusion Criteria: * Hereditary polyposis syndromes (familial adenomatous polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome) * Inflammatory bowel disease (ulcerative colitis or Crohn's disease) * Previous history of gastric or colorectal cancer * Cancer detected at initial resection (stage T1b or higher) * Non-polyp pathology (e.g., submucosal tumors, normal mucosa) * Incomplete resection with positive margins that were not re-treated * Lost to follow-up with no available surveillance data (for retrospective cohort) * Pregnancy at time of enrollment * Inability or unwillingness to provide informed consent (for prospective cohort)

Primary outcome measure(s)

Short-term Recurrence Rate at 1 Year — 1 year post-resection (10-14 months acceptable)
New polyp(s) detected by endoscopy and confirmed by pathology at 1-year follow-up. Includes both local recurrence (within 2cm of resection site) and metachronous polyps (\>2cm from original site).
Long-term Recurrence Rate at 3 Years — 3 years post-resection (33-39 months acceptable)
New polyp(s) detected by endoscopy and confirmed by pathology at 3-year follow-up. Includes both local recurrence and metachronous polyps.
Cumulative Recurrence Rate — Up to 3 years post-resection
Overall recurrence rate combining 1-year and 3-year surveillance results

Trial sites (1)

Facility	City	Region	Status
The First Hospital of Lanzhou University	Lanzhou	Gansu

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07314554 on ClinicalTrials.gov ↗ ← All trials in China