This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients diagnosed with esophageal carcinoma or benign esophageal tumors
* Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction
* Patients must have had at least one postoperative arterial blood gas analysis
* Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram
Exclusion Criteria:
* Patients who did not require esophageal reconstruction
* Patients undergoing esophageal replacement with colon
* Patients with incomplete data
Primary outcome measure(s)
Esophageal Anastomotic Leakage Rate — From the date of surgery to 30 days postoperatively Anastomotic leak was confirmed by either barium swallow study, CT scan, or endoscopy, or was clinically considered in cases with obvious salivary secretion from the cervical anastomosis.
The esophageal anastomotic leakage rate was calculated as (the number of patients with a confirmed anastomotic leakage / the total number of patients who underwent esophagectomy) × 100%.
Trial sites (6)
Facility
City
Region
Status
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center
Guangzhou
Guangdong
Recruiting
Cancer Hospital of Shantou University Medical College
Shantou
Guangdong
Recruiting
The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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