The goal of this clinical trial is to evaluate the efficacy, safety, and pharmacodynamic characteristics of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) in adults with ischemic stroke in the anterior circulation during the recovery phase. Researchers will compare hUC-MSCs to a placebo to determine whether hUC-MSCs treatment is effective in treating recovery-phase anterior circulation ischemic stroke.
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria:
* Age ≥18 years and ≤70 years, regardless of gender.
* 14 to 90 days after ischemic stroke.
* Clinical diagnosis of anterior circulation ischemic stroke.
* National Institutes of Health Stroke Scale (NIHSS) score is 6-20 points (inclusive), with NIHSS motor arm (item 5) or motor leg (item 6) score of 2-4 points, and NIHSS level of consciousness item (1a) score \<2 points.
* It was anticipated that participants would either be able to give informed consent or have a legal representative who could do so.
Exclusion Criteria:
* People who had a history of epilepsy, dementia, Parkinson's disease, severe depression, or other neurological or psychiatric disorders.
* Intracranial hemorrhagic conditions.
* Pre-stroke mRS score \>1.
* Severe cardiovascular disease.
* Severe pulmonary diseases.
Primary outcome measure(s)
Fugl-Meyer Assessment motor score — 12 months The Fugl-Meyer Assessment (FMA) is a stroke-specific, performance-based scale used to evaluate motor impairment. Its motor score, which ranges from 0 to 100, serves as a key parameter for quantifying motor recovery, where a higher score indicates better motor function.
Trial sites (1)
Facility
City
Region
Status
Xuanwu Hospital, Capital Medical University
Beijing
Beijing Municipality
More Shanghai IxCell Biotechnology Co., LTD trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time on our Cookie Policy page. See also our Privacy Policy.