CAR-T in Subjects With Relapsed/Refractory Autoimmune Disease

Inclusion Criteria: * age 18-65 years (including threshold) and gender; * positive expression of CD19 in peripheral blood B cells as determined by flow cytometry; * the function of vital organs meets the following requirements: 1. Bone marrow function needs to meet the following requirements: a. White blood cell count ≥3×109/L; b. Neutrophil count ≥1×109/L (no colony-stimulating factor treatment within 2 weeks prior to the examination); c. Hemoglobin ≥60g/L; 2. Liver function: ALT≤3×ULN (except for elevated ALT caused by inflammatory myopathy); AST≤3×ULN (except for AST elevation caused by inflammatory myopathy); TBIL≤1.5×ULN (except for Gilbert's disease). TBIL≤1.5×ULN (except Gilbert's syndrome, total bilirubin≤3.0×ULN); 3. Renal function: creatinine clearance (CrCl) ≥ 30 ml/minute (Cockcroft/Gault formula, except for disease-induced decline in CrCl); 4. Coagulation: international normalized ratio (INR) ≤ 1.5 x ULN, prothrombin time (PT) ≤ 1.5 x ULN. 5. Cardiac function: hemodynamic stability; * female subjects of childbearing potential and male subjects with a partner of childbearing potential are required to use medically approved contraception or be abstinent from sexual intercourse for at least 6 months during and after study treatment; female subjects of childbearing potential must have had a negative serum HCG test within 7 days prior to study enrollment and must not be breastfeeding; * Voluntarily participate in this clinical study and sign the informed consent form, good compliance and cooperate with follow-up visits. * Specific inclusion criteria: * Relapsed refractory systemic lupus erythematosus. * meets the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for SLE; * have a Disease Activity Score SLEDAI⁃2000 ≥ 6; and have at least one British Isles Lupus Assessment Group Index (BILAG-2004) Category A (severe manifestations) or two Category B (moderate manifestations) organ scores, or both; or have a Disease Activity Score SLEDAI-2000 ≥ 8; * Definition of relapse-refractory: failure of conventional treatment for more than 6 months or recurrence of disease activity after remission. * Relapsing Refractory/Progressive Diffuse Systemic Sclerosis * meets the 2013 ACR's classification criteria for systemic sclerosis consistent with a diffuse presentation * is positive for antibodies related to systemic sclerosis; * diffuse cutaneous sclerosis manifestations or active interstitial lung disease (HRCT suggestive of ground-glass exudates); * definition of relapsing-refractory: failure of conventional treatment for more than 6 months or recurrence of disease activity after remission. * Definition of Progressive: Rapid cutaneous progression (\>25% increase in mRSS); or pulmonary progression (10% decrease in FVC, or \>5% decrease in FVC with 15% decrease in DLCO). * Note: It is sufficient if one of Articles 4 and 5 is fulfilled. * Relapsed refractory/progressive inflammatory myopathy * meets the 2017 EULAR/ACR classification criteria for inflammatory myopathies (including DM , PM, ASS, and NM); * is positive for antibodies to myositis; * in those with muscle involvement, an MMT-8 score of less than 142 and abnormal findings on at least two of the following five core measurements (PhGA, PtGA, or Extramuscular Disease Activity Score ≥2; Total HAQ Score ≥0.25); Myosin level 1.5 times the upper limit of the normal range); or MMT-8 ≥142 in the presence of active interstitial lung disease (HRCT suggestive of ground-glass exudates); * Definition of relapse refractory: failure of conventional treatment for more than 6 months or recurrence of disease activity after remission. * Definition of progressive: the presence of exacerbation of myositis or rapidly progressive interstitial pneumonia. * Note: It is sufficient if one of Articles 4 and 5 is fulfilled. * Relapsed Refractory/Progressive Immune Thrombocytopenia * meets the 2019 American Society of Hematology (ASH) classification criteria for immune thrombocytopenia; * have bone marrow morphology characterized by increased or normal megakaryocytes with impaired maturation; * exclude other secondary thrombocytopenia * Definition of recurrent refractory: a patient who fails to achieve a satisfactory outcome after first-line standard therapy (e.g., glucocorticoids), including a full dose and course of therapy, i.e., platelet counts that cannot be maintained at a safe level (generally considered to be platelet counts \> 30 × 10⁹ /L and without overt bleeding symptoms). * Definition of progressive: a sustained decline in platelet count over the course of the disease, or a progressive worsening of bleeding symptoms, which may be accompanied by signs such as splenomegaly, and a progressively worse response to conventional therapy. * Note: It is sufficient if one of Articles 4 and 5 is fulfilled. Exclusion Criteria: * A history of severe drug allergies or sensitivities; * the presence or suspicion of fungal, bacterial, viral or other infections that are uncontrolled or require treatment * persons with central nervous system disorders caused by ADs or not caused by ADs. * those with intolerable cardiac function; * subjects with congenital immunoglobulin defects. * history of malignant tumors within the last five years. * end-stage renal failure; * subjects with positive Hepatitis B surface antigen (HBsAg), Hepatitis B core antibody (HBcAb) and peripheral blood HBV DNA titer higher than the upper limit of the test; subjects with positive antibody to Hepatitis C virus (HCV) and peripheral blood HCV RNA; subjects with positive antibody to Human Immunodeficiency Virus (HIV); and subjects with a positive test for Syphilis; * mental illness and severe cognitive impairment; * have participated in other clinical trials within 3 months prior to enrollment; * immunosuppressants or biologics with a therapeutic effect for the indication within five half-lives prior to enrollment * women who are pregnant or intend to become pregnant; * subjects who, in the opinion of the investigator, have other reasons for not being included in the study.